Rubidium-82 generator yield and efficiency for PET …
Rubidium-82 ( 82 Rb) is a widely used positron emission tomography (PET) tracer with a short half-life of ~ 75 seconds. 1 Stress perfusion imaging with 82 Rb is used widely in cardiac PET centers for the assessment of known or suspected coronary artery …
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Reliability of rubidium-82 PET/CT for renal perfusion …
The latter based on the indication that 82 Rb is primarily present in the plasma during the short duration of the dynamic PET/CT study [37, 38], as well as the observation that our previously measured 82 Rb clearance values (766 ± 114 ml/min/1.73 m 2) are similar to historically published values for ERPF [26, 39, 40].
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Reliability of rubidium-82 PET/CT for renal perfusion
In a previous study, we demonstrated that estimation of renal perfusion based on a single positron emission tomography/computed tomography (PET/CT) scan with Rubidium-82 ( 82 Rb) is feasible and found an approximate 5% intra-assay coefficient of variation for both kidneys, indicative of a precise method.This study's aim was to …
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Estimation of renal perfusion based on measurement of rubidium-82 …
We aimed to confirm the feasibility of RBF estimation based on positron emission tomography/computed tomography (PET/CT) and rubidium-82 ( 82 Rb) using the abdominal aorta as input function in a 1-tissue compartment model. Methods Eighteen healthy subjects underwent two dynamic 82 Rb PET/CT scans in two different fields of …
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Reliability of rubidium-82 PET/CT for renal perfusion …
In a previous study, we demonstrated that estimation of renal perfusion based on a single positron emission tomography/computed tomography (PET/CT) scan with Rubidium-82 (82Rb) is feasible and found an approximate 5% intra-assay coefficient of variation for both kidneys, indicative of a precise method.This study's aim was to …
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Estimation of renal perfusion based on measurement of rubidium-82 …
Conclusion. Measurement of renal perfusion based on PET/CT and 82 Rb using AA as input function in a 1-tissue compartment model is feasible in a single FOV. Based on previous studies showing 82 Rb to be primarily present in plasma, the measured K 1 clearance values are most likely representative of effective renal plasma flow (ERPF) …
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Generator-produced rubidium-82 positron
Rubidium-82 (82 Rb) is a generator-produced PET myocardial perfusion tracer and has been widely used in North America in clinical practice. 82 Rb PET has recently become available in some cardiovascular centers in …
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Cardiac PET/CT with Rb-82: optimization of image
Hybrid cardiac positron emission tomography/computed tomography (PET/CT) with 82 rubidium (82 Rb) is a useful clinical tool for the diagnosis of unknown or suspected coronary arterial disease (CAD) and microvascular disease, improving the understanding of the pathophysiology of disease processes thus directly impacting the …
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RUBY-FILL® (Rubidium Rb 82 Generator) and Elution …
The RUBY-FILL® Rubidium Rb 82 Generator contains accelerator produced Strontium-82, which decays to Rubidium-82. When the generator is eluted with saline it produces a sterile, non-pyrogenic solution of Rb-82 Chloride used for Cardiac Positron Emission Tomography (PET), a non-invasive imaging procedure of the myocardium, to evaluate …
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Rubidium 82
Rubidium-82. 82 Rb is produced from a strontium-82 ( 82 Sr)/ 82 Rb generator, which can be eluted every 10 minutes. 27 The T 1/2 of 82 Sr is 25.5 days, which results in a generator life of 6 to 8 weeks. The short T 1/2 of 82 Rb (76 seconds) allows repeated and sequential perfusion studies but requires rapid image acquisition shortly after ...
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STC-23-049 Notification Of Issuance For Public …
Rulemaking Plan to Establish Requirements for Rubidium-82 Generators and Emerging Medical Technologies," dated January 13, 2022 (ML22013A266). Discussion: On July 3, 2023, the NRC published a notice in the Federal Register announcing the availability of this regulatory basis document for a 120-day public comment period (see 88 FR 42654).
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Generator-produced rubidium-82 positron
Utilization statistics and diagnostic accuracy of a nonhospital-based positron emission tomography center for the detection of coronary artery disease using rubidium-82. Am J Physiol Imaging. 1992; 7 : 203-209
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Rubidium-82 generator yield and efficiency for PET …
Introduction. Rubidium-82 (82 Rb) is a widely used positron emission tomography (PET) tracer with a short half-life of ~ 75 seconds.1 Stress perfusion imaging with 82 Rb is used widely in cardiac PET centers for the assessment of known or suspected coronary artery disease.2 The short half-life of 82 Rb allows rapid sequential rest and …
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Reliability of rubidium-82 PET/CT for renal perfusion …
In a previous study, we demonstrated that estimation of renal perfusion based on a single positron emission tomography/computed tomography (PET/CT) scan …
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Myocardial perfusion scintigraphy using rubidium-82 …
The 'Evidence based indications for the use of PET CT in the United Kingdom', recommend the use of both 13 N-ammonia and 82 Rb MPS as alternatives to SPECT. 34 Against this 82 Rb MPS is currently available in only two centres: at our institution and at University College Hospital, London.
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Review: comparison of PET rubidium-82 with conventional …
1 ). 82 Rb- PET was demonstrated to have superior accuracy in comparison with 99m Tc- SPECT with both ECG-gating and attenuation correction (Mc Ardle et al ., 2012 ). Figure 1. 82 Rb Cardiac PET; pharmacological stress test (adenosine) and rest test of a patient with suspected ischaemic heart disease.
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Story of Rubidium-82 and Advantages for Myocardial …
Rubidium-82 has a long story, starting in 1954. ... Pooled patient-based sensitivity and specificity were, respectively, 0.91 and 0.90. By comparison with (99m)Tc-SPECT, (82)Rb PET had a much better diagnostic accuracy, especially in obese patients with body mass index ≥30 kg/m(2) (85 versus 67% with SPECT) and in women with …
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Rubidium-82 Generators, Emerging Technologies, and …
The regulatory basis, titled "Rubidium-82 Generators, Emerging Technologies, and Other Medical Use of Byproduct Material—Regulatory Basis," can be obtained at ADAMS Accession No. ML23122A356. ... The analyses are based on the NRC's preliminary assessment and estimates, and the NRC will conduct a more detailed …
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Draft Regulatory Basis Document for the Rulemaking to …
Rubidium-82 Generators and Emerging Medical Technologies," dated January 13, 2022 ... based requirements for existing EMTs based on operating experience,and (3) revise other outdated, prescriptive requirements with risk-informed, …
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Frontiers | Story of Rubidium-82 and Advantages …
Rubidium-82 has a long story, starting in 1954. After preclinical studies in dogs showing that myocardial uptake of this radionuclide was directly proportional to myocardial blood flow (MBF), clinical studies were …
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Rubidium 82
Rubidium-82 (Rb-82) and nitrogen-13 (N-13) ammonia are clinically used PET perfusion tracers, whereas oxygen-15 (O-15) water is a research perfusion tracer. Rb-82 is the …
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Rubidium 82
Rubidium-82 (Rb-82) and nitrogen-13 (N-13) ammonia are clinically used PET perfusion tracers, whereas oxygen-15 (O-15) water is a research perfusion tracer. Rb-82 is the most commonly used PET perfusion tracer, with a half-life of 76 seconds, and is produced by a strontium-83 generator. ... The Rb-82 PI reports dosimetry values based on data ...
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Cardiac PET/CT with Rb-82: optimization of image …
Background. Hybrid cardiac positron emission tomography/computed tomography (PET/CT) with 82 rubidium (82 Rb) is a useful clinical tool for the diagnosis of unknown or suspected coronary arterial disease (CAD) and microvascular disease, improving the understanding of the pathophysiology of disease processes thus directly …
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Estimation of renal perfusion based on measurement of Rubidium-82 …
We aimed to confirm the feasibility of RBF estimation based on positron emission tomography/ computed tomography (PET/CT) and rubidium-82 (⁸²Rb) using the abdominal aorta as input function in a ...
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Rubidium Rb 82 (Intravenous Route) Precautions
Precautions. Drug information provided by: Merative, Micromedex ®. It is very important that your doctor check your progress very closely while you are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it. You might receive a medicine to make your ...
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Rubidium-82 Cardiac Positron Emission Tomography
This review highlights the role of Rb-82 in PET myocardial perfusion imaging and provides an overview of its properties, its diagnostic accuracy for diagnosing coronary artery disease and myocardIAL viability, and some unique applications. Cardiac positron emission tomography (PET) imaging has been used for more than 3 decades to study …
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Cardiogen-82 (rubidium Rb 82 generator): Side Effects, Uses
Dosage Forms And Strengths. CardioGen-82 is a closed system used to produce rubidium Rb 82 chloride injection for intravenous use. CardioGen-82 consists of strontium Sr-82 adsorbed on a hydrous stannic oxide column with an activity of 90-150 millicuries Sr-82 at calibration time.
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Rubidium 82
Rubidium-82. 82 Rb is produced from a strontium-82 ( 82 Sr)/ 82 Rb generator, which can be eluted every 10 minutes. 27 The T 1/2 of 82 Sr is 25.5 days, which results in a …
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Study updates dose estimates for rubidium-82 cardiac PET
Rubidium-82 is increasingly being used for cardiac PET imaging, but radiation dose estimates for the exams are based on old -- and conflicting -- data. Researchers from Johns Hopkins University offer updated dose estimates for rubidium-82 procedures in a study published in the October issue of the Journal of Nuclear Medicine.
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RUBY-FILL- rubidium rb 82 injection, solution Jubilant …
The recommended weight-based dose of rubidium Rb 82 chloride to be administered per rest or stress component of a PET myocardial perfusion imaging (MPI) procedure is between 10-30 Megabecquerels (MBq)/kg [0.27-0.81 millicuries (mCi)/kg]. Do not exceed a single dose of 2220 MBq (60 mCi).
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